Selected Publications

Selected Publications


Lake JI and Heuckeroth RO (2013) Enteric nervous system development, migration, differentiation and disease, American Journal of Physiology - Gastrointestinal and Liver Physiology, 305(1):G1-24 [PubMed] [Full Article]


Peer Reviewed Manuscripts:

Fu M, Landreville S, Agapova OA, Wiley LA, Shoykhet M, Harbour JW, Heuckeroth RO (2013) Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction, The Journal of Clinical Investigation 123(12): 5152-64 [PubMed]

Lake JI, Tusheva OA, Graham BL, Heuckeroth RO (2013) Hirschsprung-like disease is exacerbated by reduced de novo GMP synthesis, The Journal of Clinical Investigation 123(11): 4875-87 [PubMed]

Wright-Jin EC, Grider JR, Duester G, Heuckeroth RO (2013) Retinaldehyde dehydrogenase enzymes regulate colon enteric nervous system structure and function, Developmental Biology 381(1): 28-37 [PubMed]

Hitch MC, Leinicke JA, Wakeman D, Guo J, Erwin CR, Rowland KJ, Merrick EC, Heuckeroth RO, Warner BW (2012) Ret heterozygous mice have enhanced intestinal adaptation after massive small bowel resection, American Journal of Physiology - Gastrointestinal & Liver Physiology 302(10): G1143-50, May 15 2012. [PubMed]

Viader A, Wright-Jin EC, Vohra BP, Heuckeroth RO, Milbrandt J (2011) Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction, PLoS One 6(11):e27727 [PubMed]

Wang H, Hughes I, Planer W, Parsadanian A, Grider JR, Vohra BPS, Keller-Peck C, Heuckeroth RO (2010) The timing and location of GDNF expression determines enteric nervous system structure and function, Journal of Neuroscience, 30(4), 1523-38. [PubMed]

Fu M, Sato Y, Lyons-Warren A, Zhang B, Kane MA, Napoli JL, Heuckeroth RO (2010) Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation, Development, 137(4), 631-40. [PubMed]

Wang H, Malone JP, Gilmore PE, Davis AE, Magee J, Townsend RR, Heuckeroth RO (2010) Serum markers may distinguish biliary atresia from other forms of neonatal cholestasis, Journal of Pediatric Gastroenterolology and Nutrition 50(4): 411-645. [PubMed]

Sato Y, Heuckeroth RO (2008) Retinoic acid regulates murine enteric nervous system precursor proliferation, enhances neuronal precursor differentiation, and reduces neurite growth in vitro, Developmental Biology 320(1):185-98. [PubMed]

Vohra BP, Planer W, Armon J, Fu M, Jain S, Heuckeroth RO (2007) Reduced endothelin converting enzyme-1 and endothelin-3 mRNA in the developing bowel of male mice may increase expressivity and penetrance of Hirschsprung disease-like distal intestinal aganglionosis. Developmental Dynamics 236(1):106-17. [PubMed]

Fu M, Vohra BP, Wind D, Heuckeroth RO (2006) BMP signaling regulates murine enteric nervoys system precursor migration, neurite fasciculation, and patterning via altered Ncam1 polysialic acid addition, Developmental Biology, 299(1):137-50 [PubMed]

Vohra BP, Tsuji K, Nagashimada M, Uesaka T, Wind D, Fu M, Armon J, Enomoto H, Heuckeroth RO (2006) Differential gene expression and functional analysis implicate novel mechanisms in enteric nervous system precursor migration and neurogenesis. Developmental Biology 298(1):259-71 [PubMed]

Wang H, Vohra BP, Zhang Y, Heuckeroth RO (2005) Transcriptional profiling after bild duct ligation identifies PAI-1 as a contributor to cholestatic liver injury in mice. Hepatology, 42(5):1099-108. [PubMed]

Gianino S, Grider JR, Cresswell J, Enomoto H, Heuckeroth RO (2003) GDNF availability determines enteric neuron number by controlling precursor proliferation, Development, 130(10):2187-98. [PubMed]

Heuckeroth RO, Enomoto H, Grider JR, Golden JP, Hanke JA, Jackman A, Molliver DC, Bardgett ME, Snider WD, Johnson EM Jr, Milbrandt J (1999) Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory and sympathetic neurons, Neuron 1999 Feb;22(2):253-63. [PubMed]