Selected Publications

Selected Publications


Lake JI and Heuckeroth RO (2013) Enteric nervous system development, migration, differentiation and disease, American Journal of Physiology - Gastrointestinal and Liver Physiology, 305(1):G1-24 [PubMed] [Full Article]

Avetisyan M, Schill EM, Heuckeroth RO (2015) Building a second brain in the bowel, The Journal of Clinical Investigation, 125, 899-906


Peer Reviewed Manuscripts:

Wright CM, Garifallou JP, Schneider S, Mentch HL, Kothakapa DR, Maguire BA, & Heuckeroth RO (2020) Dlx1/2 mice have abnormal enteric nervous system function, JCI insight 5(4), e131494 [Full Article]

Graham KD, López SH, Sengupta R, Shenoy A, Schneider S, Wright CM, Feldman M, Furth E, Valdivieso F, Lemke A, Wilkins BJ, Naji A, Doolin EJ, Howard MJ, & Heuckeroth RO (2020) Robust, 3-Dimensional Visualization of Human Colon Enteric Nervous System Without Tissue Sectioning, Gastroenterology 158(8), 2221–2235.e5 [Full Article]

Schill EM, Wright CM, Jamil A, LaCombe JM, Roper RJ, & Heuckeroth RO (2019) Down syndrome mouse models have an abnormal enteric nervous system, JCI insight 5(11), e124510 [Full Article]

López SH, Avetisyan M, Wright CM, Mesbah K, Kelly RG, Moon AM, & Heuckeroth RO (2018) Loss of Tbx3 in murine neural crest reduces enteric glia and causes cleft palate, but does not influence heart development or bowel transit, Developmental biology 444 Suppl 1(Suppl 1), S337–S351 [Full Article]

Avetisyan M, Rood JE, Huerta Lopez S, Sengupta R, Wright-Jin E, Dougherty JD, Behrens EM, & Heuckeroth RO (2018) Muscularis macrophage development in the absence of an enteric nervous system, Proceedings of the National Academy of Sciences of the United States of America115(18), 4696–4701 [Full Article]

Schill EM, Lake JI, Tusheva OA, Nagy N, Bery SK, Foster L, Avetisyan M, Johnson SL, Stenson WF, Goldstein AM, & Heuckeroth RO (2016) Ibuprofen slows migration and inhibits bowel colonization by enteric nervous system precursors in zebrafish, chick and mouse, Developmental biology 409(2), 473–488 [Full Article]

Lake JI, Avetisyan M, Zimmermann AG, & Heuckeroth RO (2016) Neural crest requires Impdh2 for development of the enteric nervous system, great vessels, and craniofacial skeleton, Developmental biology 409(1), 152–165 [Full Article]

Avetisyan M, Wang H, Schill EM, Bery S, Grider JR, Hassell JA, Stappenbeck T, & Heuckeroth RO (2015) Hepatocyte Growth Factor and MET Support Mouse Enteric Nervous System Development, the Peristaltic Response, and Intestinal Epithelial Proliferation in Response to Injury, The Journal of neuroscience : the official journal of the Society for Neuroscience 35(33), 11543–11558 [Full Article]

Schrenk S, Schuster A, Klotz M, Schleser F, Lake J, Heuckeroth RO, Kim YJ, Laschke MW, Menger MD, & Schäfer KH (2015) Vascular and neural stem cells in the gut: do they need each other? Histochemistry and cell biology 143(4), 397–410 [Full Article]

Fu M, Landreville S, Agapova OA, Wiley LA, Shoykhet M, Harbour JW, Heuckeroth RO (2013) Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction, The Journal of Clinical Investigation 123(12): 5152-64 [PubMed]

Lake JI, Tusheva OA, Graham BL, Heuckeroth RO (2013) Hirschsprung-like disease is exacerbated by reduced de novo GMP synthesis, The Journal of Clinical Investigation 123(11): 4875-87 [PubMed]

Wright-Jin EC, Grider JR, Duester G, Heuckeroth RO (2013) Retinaldehyde dehydrogenase enzymes regulate colon enteric nervous system structure and function, Developmental Biology 381(1): 28-37 [PubMed]

Hitch MC, Leinicke JA, Wakeman D, Guo J, Erwin CR, Rowland KJ, Merrick EC, Heuckeroth RO, Warner BW (2012) Ret heterozygous mice have enhanced intestinal adaptation after massive small bowel resection, American Journal of Physiology - Gastrointestinal & Liver Physiology 302(10): G1143-50, May 15 2012. [PubMed]

Viader A, Wright-Jin EC, Vohra BP, Heuckeroth RO, Milbrandt J (2011) Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction, PLoS One 6(11):e27727 [PubMed]

Wang H, Hughes I, Planer W, Parsadanian A, Grider JR, Vohra BPS, Keller-Peck C, Heuckeroth RO (2010) The timing and location of GDNF expression determines enteric nervous system structure and function, Journal of Neuroscience, 30(4), 1523-38. [PubMed]

Fu M, Sato Y, Lyons-Warren A, Zhang B, Kane MA, Napoli JL, Heuckeroth RO (2010) Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation, Development, 137(4), 631-40. [PubMed]

Wang H, Malone JP, Gilmore PE, Davis AE, Magee J, Townsend RR, Heuckeroth RO (2010) Serum markers may distinguish biliary atresia from other forms of neonatal cholestasis, Journal of Pediatric Gastroenterolology and Nutrition 50(4): 411-645. [PubMed]

Sato Y, Heuckeroth RO (2008) Retinoic acid regulates murine enteric nervous system precursor proliferation, enhances neuronal precursor differentiation, and reduces neurite growth in vitro, Developmental Biology 320(1):185-98. [PubMed]

Vohra BP, Planer W, Armon J, Fu M, Jain S, Heuckeroth RO (2007) Reduced endothelin converting enzyme-1 and endothelin-3 mRNA in the developing bowel of male mice may increase expressivity and penetrance of Hirschsprung disease-like distal intestinal aganglionosis. Developmental Dynamics 236(1):106-17. [PubMed]

Fu M, Vohra BP, Wind D, Heuckeroth RO (2006) BMP signaling regulates murine enteric nervoys system precursor migration, neurite fasciculation, and patterning via altered Ncam1 polysialic acid addition, Developmental Biology, 299(1):137-50 [PubMed]

Vohra BP, Tsuji K, Nagashimada M, Uesaka T, Wind D, Fu M, Armon J, Enomoto H, Heuckeroth RO (2006) Differential gene expression and functional analysis implicate novel mechanisms in enteric nervous system precursor migration and neurogenesis. Developmental Biology 298(1):259-71 [PubMed]

Wang H, Vohra BP, Zhang Y, Heuckeroth RO (2005) Transcriptional profiling after bild duct ligation identifies PAI-1 as a contributor to cholestatic liver injury in mice. Hepatology, 42(5):1099-108. [PubMed]

Gianino S, Grider JR, Cresswell J, Enomoto H, Heuckeroth RO (2003) GDNF availability determines enteric neuron number by controlling precursor proliferation, Development, 130(10):2187-98. [PubMed]

Heuckeroth RO, Enomoto H, Grider JR, Golden JP, Hanke JA, Jackman A, Molliver DC, Bardgett ME, Snider WD, Johnson EM Jr, Milbrandt J (1999) Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory and sympathetic neurons, Neuron 1999 Feb;22(2):253-63. [PubMed]